Understanding the endocannabinoid system (ECS)

The endocannabinoid system is an endogenous signalling network that modulates nearly every organ system — pain, immunity, appetite, sleep, stress. It comprises at least two G-protein-coupled receptors (CB1, CB2), two main ligands (anandamide, 2-AG) and the degrading enzymes FAAH and MAGL. This is why phytocannabinoids like THC and CBD have any effect at all.